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Due to the interference with DNMTs capacity to bind DNA, hydroxyl radicals (HO) also encourage global hypomethylation

S., Sharma, L

By integrating transcriptomic and untargeted metabolomic analyses of BM neutrophils, we revealed a pivotal role for Chac2-driven GSH metabolic reprogramming in skewing neutrophils toward the N1 phenotype, which is orchestrated by upstream IFN-I signaling