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Immunotherapeutic maintenance treatment with toll-like receptor 9 agonist lefitolimod in patients with extensive-stage small-cell lung cancer: Results from the exploratory, controlled, randomized, international phase ii impulse study

Moreover, increased expression of interferon- (IFN-), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor-1 (TGF-1), IL-8, IL-6, and TNF- and other genes associated with the immune response have been reported in those brain regions and in the cerebrospinal fluid [4850] (Figure 4)