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Large population studies now show that women who experience severe or early-onset hot flashes are more likely to exhibit changes in arterial health, including endothelial dysfunction and subclinical atherosclerosis

Doctors might adjust this based on how the patient responds and their health

It has been shown to modulate nitric oxide and growth factor activity, which enhances blood flow and nutrient delivery to damaged tissue

It is secreted by the adipose tissue, and its levels are increased in diet-induced and genetic forms of obesity [200]

Acute worsening (increased bleeding, severe pain, prolapse) indicates mechanical or vascular instability requiring intervention, not a peptide protocol adjustment