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To further dissect these loci and investigate the biological relationships linking brain structure, function, and AD, we conducted four follow-up analyses: (1) Bayesian colocalization to identify shared causal variants, (2) identification of pleiotropic SNPs shared between AD and imaging traits, (3) classification of their effect directions as concordant or antagonistic, and (4) mapping shared regions to potential effector genes

Building on these results, a follow-up study was conducted to examine the hippocampal neuroproteome following environmental enrichment, which has been demonstrated to increase neuronal activity and induce spatial learning and memory formation, on the hippocampal neuroproteome (McNair et al., Exercise is known to improve neuronal activity and cognitive function, and exerts neuroprotective effects in aging hippocampus (O'Callaghan et al., 2010)

The process of forming ATP creates many harmful byproducts

Mechanism of Action: PT-141 binds to melanocortin receptors (MC3-R and MC4-R) in the hypothalamus in the brain

Heliyon 9 (9), e19496