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Neuropathic pain, a typical neurodegenerative disease, is also inextricably linked to ferroptosis (Wang et al., 2021)

Egunsola AT, Bae Y, Jiang MM, Liu DS, Chen-Evenson Y, Bertin T, Chen S, Lu JT, Nevarez L, Magal N, Raas-Rothschild A, Swindell EC, Cohn DH, Gibbs RA, Campeau PM, Shohat M, Lee BH, "Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia", The Journal of clinical investigation 127 (4): 1475-1484 (2017)

GO analysis further showed that uridine supplementation restored biological processes in aged oocytes, including oxidative stress responses, iron ion homeostasis regulation, lipid metabolism, oxidative phosphorylation, cell cycle regulation, and DNA repair (Fig

9 This in turn promotes the accumulation of reactive oxygen species