bacterial and host-derived glutathione are required to activate prfa Discovery of a utilization pathway in Francisella that shows functional divergence between environmental pathogenic species: Cell Host & Microbe Frontiers | Metabolic host responses

Frontiers Metabolic host responses to infection by intracellular bacterial pathogens Listeria monocytogenes utilizes glutathione and limited inorganic sulfur compounds as sources of essential cysteine Infection and Immunity Multiple regulatory check points control prfA expression and protein Download Scientific Diagram Glutathione metabolism impacts fungal virulence by modulating the redox environment bioRxiv Allosteric GSH binding primes PrfA for DNA binding. (A and B) Download Scientific Diagram

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