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In HF, diminished left ventricular (LV) output elevates pulmonary venous pressure, driving interstitial fluid leakage and pulmonary edema, which impairs oxygen diffusion and precipitates dyspnea

These studies have shown that the loss of wt-p53 and/or GOF of p53 aids in the progression of GBM and may be an effective clinical target

In the in vitro tests, the endothelia were perfused for 1 - 3 h with a balanced salt solution containing 250 mg ethylene oxide, 2250 mg 2-chloroethanol, or 5000 mg 1,2-ethanediol/litre

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