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How much oxidant is delivered follows a non-linear doseresponse in which modest H 2 O 2 enhances signalling through reversible thiol switches, whereas high local fluxes ignite injury chemistry, including OH generation from H 2 O 2 at iron-rich sites (Goulev et al

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Mechanistically, p53 decreases the monoubiquitination rate of histone H2B on lysine 120 (H2Bub1) in the SLC7A11 gene regulatory region by facilitating the nuclear translocation of the deubiquitinase USP7, leading to the inactivation of SLC7A11 expression in erastin-treated cells [122]