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Sequential homoharringtonine (HHT) and interferon (IFN-A) produce high hematologic and cytogenetic response rates in Philadelphia chromosome positive (Ph) chronic myelogenous leukemia (CML)

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They showed that a hypoxia-mediated redox imbalance promotes the release of Ca 2+ from the endoplasmic reticulum and activates the non-receptor protein tyrosine kinase Src at the plasma membrane