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Lodish (1992) Science 257, 14961502

doi: 10.1038/s41586-023-06267-2

by buthionine sulfoximine (BSO) which is a transition state inactivator of glutamate cysteine ligase (GCL) that catalyzes the first limiting step of GSH synthesis

Lipid peroxidation overwhelms cellular repair systems, such as the glutathione peroxidase 4 (GPX4) pathway, the ferroptosis suppressor protein 1 (FSP1) pathway, and the GTP cyclohydrolase 1 (GCH1) pathway, leading to cell death 10