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Under endotoxin shock, the activity of the key antioxidant enzyme Glutathione Peroxidase 4 (GPX4) in alveolar epithelial cells decreases significantly, leading to the lethal accumulation of lipid peroxides on membrane systems (54)
Cognitive and neuroprotective effects of chlorogenic acid
Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon alfa administration
Disclosures: Vivian Rotman: Nothing to Disclose, Ana Carolina Cardoso: Nothing to Disclose, MARIA CHIARA CHINDAMO: Nothing to Disclose, Adriana Bottino: Nothing to Disclose, Joao Marcello de Araujo-Neto: Nothing to Disclose, aline ferraz pereira: Nothing to Disclose, LAIS Veiga: Nothing to Disclose, Nathalia Carraro Eduardo de Castro: Nothing to Disclose, DEBORA Canoilas: Nothing to Disclose, Andreia Evangelista: Nothing to Disclose, Renata Perez: Nothing to Disclose 2448 BURDEN OF COMORBID PSYCHIATRIC ILLNESSES AMONG HOSPITALIZED PATIENTS WITH AUTOIMMUNE LIVER DISEASE: A NATIONWIDE COHORT ANALYSIS Carla Barberan Parraga 1 Leandro Sierra 2 Diana Cheung 1 Kundan Jana 1 Marwan Alsaqa 3 Nazli Begum Ozturk 4 Butros Fakhoury 5 Syed Kodilinye 1 Ahmed Salem 1 Yasutoshi Shiratori 1 James Park 6 , 1 Maimonides Medical Center, 2 Beth Israel Deaconess Medical Center, 3 BIDMC HMS, 4 Beaumont Hospital, Royal Oak, 5 St Elizabeth's Medical Center, 6 Northwell Health Background: Autoimmune liver disease patients experience significant cognitive decline, which is linked to anxiety and depression, increasing the risk of unplanned hospitalizations, hepatic encephalopathy admissions, and mortality
