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HS- 173 selectively activates RIP3 and MLKL, inducing necroptosis in RIP3-expressing NSCLC cells and suppressing tumor growth in mouse models (Park et al

JAK-STAT pathway alterations impair immune homeostasis by affecting immune cell development and function

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this effect can be reversed by sulforaphane, a molecule with chemopreventive ability, and, in fact, represents a potential mechanism of action for sulforaphane-mediated induction of NRF2 [235]