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Perhaps the closest he comes to this consideration might be his mention of nostril dilation in fearful horses, but he argues that this is the result of an association between fear and the exertions of rapid flight (Darwin, Reference Darwin1872: 130), rather than functioning to detect a source of danger

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Policy Note: This is an abridged version of an article originally published in the Cleveland Clinic Journal of Medicine

The peptide-coding regions of binding-enriched phage pools were PCR-amplified and barcoded with Phusion High-Fidelity polymerase (Thermo Scientific)