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At 12 h post-PPD injection, PTT elevates localized temperatures to approximately 48.5 C, prompting hemoglobin to release oxygen and transiently alleviate hypoxia within the TME for enhanced PTT/RT (Fig

& Nolta, J

Glorieux C, Sandoval JM, Fattaccioli A, Dejeans N et al (2016) Chromatin remodeling regulates catalase expression during cancer cells adaptation to chronic oxidative stress