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Further, it is also important to keep in mind that cancer cells can also acquire resistance to epigenetic therapies, which can then interfere with the expression of genes involved in cell cycle regulation, DNA repair, and apoptosis, making therapies become inefficient

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linear flow rate 250 cm/h Chemical stability stable in 0.1 M acetate pH 4.0, 0.1 M NaOH, 70 % ethanol or 6 M guanidine hydrochloride for two hours at room temperature, not autoclavable * Tested with human Glutathione S-transferase (GST) Recommended flow rates With a bed volume of 1 ml (10 ml) and an inner diameter of 6.6 mm (16 mm) the flow rates for sample loading should be 0.2 1.0 ml/min (0.5 - 5.0 ml/min) and 1.0 ml/min (5.0 ml/min) for washing/elution

[DOI] [PMC free article] [PubMed] [Google Scholar] Oja SS, Janaky R, Varga V, Saranasaari P

& Bollenbach, A