Benzyl alcohol, commonly used as a preservative in injectable b12 products, can cause reactions in sensitive individuals
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In a colorectal cancer (CRC) lung metastasis model, gut dysbiosis-induced TCA accumulation promoted M-MDSC expansion and immunosuppressive function by enhancing glycolysis and epigenetically stabilizing PD-L1 expression via H3K4 mono-methylation, with potential involvement of the Farnesoid X Receptor (FXR) ( Conversely, targeting BA metabolism offers a promising strategy to reduce MDSC-mediated immunosuppression
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