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AGING AND ACETYLTRANSFERASES Although cellular senescence, a state of persistent cell cycle arrest, may primarily serve as a cardioprotective mechanism to preserve functional cardiomyocytes, senescent cells also release pro-inflammatory cytokines, collectively known as the senescence-associated secretory phenotype (SASP)

The symptoms gradually worsen from infancy to early adulthood

Marchesi, J

Collectively, these findings indicate that microbiota-targeted therapy offers a promising therapeutic paradigm for the precise intervention of TMAO-related diseases