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The progestogen component lowers LH levels, indirectly reducing the production of androgens in the ovaries and increasing the level of sex hormone binding globulin

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For example, punicalagin intervention significantly enriched short-chain fatty acid-producing bacteria such as Akkermansia muciniphila and Ruminiclostridium 9 in the intestines of high-fat diet mice (Gao et al., 2024), while also increasing the abundance of Lachnospiraceae NK4A136 and Bifidobacterium , which have bile acid metabolism functions (Liu et al., 2024)

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