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Demonstrates marked gastroprotective and ulcer-healing activity in rodent models of IBD, NSAID damage, and fistula formation, mirroring the protective role of the parent protein in human gastric juice is exposed to daily

All images were measured using the ImageJ freehand drawing or ellipse tool to outline the organoid and the automated measure tool to calculate the perimeter based on the calibrated scale for image magnification at 20x

1) Oxidative block irreversible, makes NADPH and CO Step 1: G6P + NADP 6-phosphogluconolactone + NADPH via G6PD (rate-limiting) Step 2: lactone + HO 6-phosphogluconate Step 3: 6-PG + NADP ribulose-5-P (Ru5P) + CO + NADPH Net per G6P: 2 NADPH + CO + Ru5P 2) Non-oxidative block reversible sugar shuffling Ru5P ribose-5-P (R5P) or xylulose-5-P (Xu5P) Transketolase (TPP-dependent) moves 2-carbon pieces: Xu5P + R5P sedoheptulose-7-P + GAP

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