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Visualization of predicted binding pockets in the protein structure showing different potential ligand-binding sites: (a) primary binding pocket highlighted in red, (b) secondary surface pockets highlighted in blue, (c) ligand-interacting cavity highlighted in yellow with bound conformation, and (d) another potential internal binding pocket highlighted in yellow within the protein structure Figure 8

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WB analysis of extracts from OVCAR8 cells, transfected with 100 nM SignalSilence Control siRNA (Unconjugated) #6568 (-), SignalSilence KEAP1 siRNA I #5285 (+) or SignalSilence KEAP1 siRNA II #5289 (+), using recombinant monoclonal antibody KEAP1 (D6B12) Rabbit mAb #8047 (upper) or -Tubulin (11H10) Rabbit mAb #2125 (lower)

J Pharmacogn Phytochem 8:686693 Ross SM, McManus IC, Harrison V, Mason O (2013) Neurobehavioral problems following low-level exposure to organophosphate pesticides: a systematic and meta-analytic review

The activity of an enzyme can be influenced by the availability of cofactors, the concentration of substrates, the oxidative status, post-translational modifications or by inhibitors