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The Aib (2aminoisobutyric acid) residue at the Nterminus improves resistance to enzymatic degradation, while modified amino acids such as D2naphthylalanine and Dphenylalanine enhance laboratory stability

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These reactive glial barriers are, arguably, protective against -amyloid toxicity 195,196 , whereas suppression of reactive astrogliosis exacerbates pathology in AD animal models 197

(2) The 3 most recent years prior to the start of the ACO's agreement period used in establishing the historical benchmark, when such a benchmark is used to reconcile the ACO for a performance year adjusted in accordance with paragraph (d)(1) of this section

Knstler et al., 2016)