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Its capacity to carry oxygen may improve oxygen delivery, especially at Po below 60 mm Hg, where it has a higher affinity for oxygen than Hb

Poly(ADP-ribose) polymerase 1 regulates mitochondrial DNA repair in an NAD-dependent manner

In vivo studies in bleomycin mouse models of pulmonary fibrosis have shown that the administration of the hypoglycemic agent metformin attenuates lung fibrosis [44]

During the blinded data review an indication of period effect was noted and properly registered as follow up action according to the Statistical Analysis Plan of the trial protocol

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