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Hoenderop, J

M.SnyderA

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Current preclinical and clinical investigations are assessing inhibitors targeting components of this pathway, including PI3K, AKT and mTOR, both as monotherapies and in combination regimens, with the aim of overcoming therapeutic resistance and improving patient outcomes (3638)

The exact mechanisms behind oligodendrocyte degeneration are not fully understood, but may include mitochondrial disruption due to a cuprizone-induced copper deficit, ferroptosis (Jhelum, 2020), and endoplasmic reticulum stress responses