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R., Thiemann, P

The ongoing assessment of the patients condition is crucial in determining the duration and frequency of therapy, making adjustments as necessary based on therapeutic response and any changes in the patients health status

19,20 The increase in mucus production, and the decrease in CFTR activity can precede COPD and persist once disease is established, 21 indicating that the presence of oxidant stress plays a role in the early onset of disease and is an attractive therapeutic target

This metabolic imbalance contributes to increased lipid peroxidation, as indicated by high malondialdehyde (MDA) levels (Chauhan et al., 2004), and is exacerbated by a concomitant reduction in antioxidant defenses

13 :530 Corresponding authors: Ding-Sheng Jiang, MD, Division of Cardiovascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan 430030, China