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Nat Rev Gastroentero Hepat

However, some biotransformation products have enhanced activity or toxic properties

To assess the efficacy of DFO in protecting the kidney cells against iron toxicity, HEK293T and HK-2 cells were exposed to 10 M DFO for 2 h before or after treated with iron overload conditions

Additionally, IL-6 and IL-23 can drive Th 17 differentiation, with IL-17 recruiting neutrophils that infiltrate thyroid tissue, causing direct damage to follicular epithelial cells (Stadhouders et al., 2018)