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Histological analysis revealed that anagen hair follicles in anti-VEGFtreated mice were thinner (Figure 5, c and d) with a more than 30% reduction in bulb diameters (Figure 5e), mainly due to reduced thickness of the follicular epithelium, associated with a significant, more than 40% decrease of perifollicular vascularization (Figure 5, f and g)

Animal studies of TB-4 and its derivative TB-500 show that these peptides promote tissue repair and angiogenesis, the process by which new blood vessels are formed

Jaspers, S., Hopermann, H., Sauermann, G., Hoppe, U., Lunderstdt, R., & Ennen, J

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& Udupa, S