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Acting as an autocrine or paracrine hormone, FGF21 appears both to induce pathways that restore protein homeostasis, for example by enhancing TFEB-dependent lysosomal biogenesis to enable turnover of damaged proteins (154, 155)

The clinical and biological manifestations that may be encountered reflect both exaggerated therapeutic effect and impairment in metabolic pathways

Ferroptosis contributes to neuronal death and functional outcome after traumatic brain injury

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Regulation of ferroptosis Iron-related pathways Iron is an indispensable metal for the body and is essential for maintaining biological homoeostasis