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doi: 10.1002/advs.202303473 252 ZhuL.JiaX.XieH.ZhangJ.ZhuQ

Astrocytes and amyotrophic lateral sclerosis/motor neuron diseases Motor neurons are damaged by oxidative stress and reactive astrogliosis in ALS patients (Rao and Weiss, 2004

Subsequent work by Itoh et al

The method according to claim 1 or 2, the use according to any one of claims 3-6, or the composition according to claim 7 or 8, wherein the composition further comprises a pharmaceutically acceptable excipient, carrier, or diluent

Additionally, defective de novo NAD + synthesis has also demonstrated to be a contributing factor in the decrease of renal NAD + levels, especially in the context of renal IRI, which causes a reduction in the expression of de novo NAD + biosynthetic enzymes and the accumulation of certain intermediates, such as quinolinate [146, 147]