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Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis

8 A 2005 review framed T4 memorably as an actin-sequestering protein that moonlights to repair injured tissues when released after injury

doi: 10.1016/B978-0-12-405881-1.00002-1 595 World Health Organization

FIGURE 1 3.1.1.3 Cancer metastasis and ROS Excessive level of ROS leads to metastasis via the stimulation of mitogen-activated protein kinase (MAPK), and phosphoinositide-3-kinase regulatory subunit/AKT serine/threonine kinases/mechanistic target of rapamycin kinase (PI2K/Akt/mTOR) signaling pathways that directs the activation of downstream metalloproteinase 9 (MMP9), metalloproteinase 2 (MMP2), SNAIL enzymes which initiate epithelial-mesenchymal transition (EMT) to metastasis (Deepika et al., 2013)

These trends were consistent with the qPCR analyses of ACSL4 , GPX4 , and FTH1 (Supplementary Fig