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This observation was in line with the immunofluorescence analysis, which indicated that in fibrotic-like assembloids some hepatocytes (HNF4A + GFP ) were positive for the cholangiocyte marker KRT19, and opened lumina, resembling the polarity of simple ductal epithelium, suggestive of potential hepatocyte-to-duct transdifferentiation (Extended Data Fig

17 Henao-MejiaJ.ElinavE.JinC.HaoL.MehalW

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By picking the low hanging fruit, we focus on addressing the manifestations that are almost always present in Hashimotos and relatively easy to correct with simple, yet targeted changes

Peer review Peer review information Nature Cardiovascula r Research thanks the anonymous reviewers for their contribution to the peer review of this work