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While glutamine and glycine are usually abundant in a standard diet, cysteine is often the "limiting factor." Think of it like a construction project where you have plenty of wood and glass but are short on steel beams

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However, if this were true, the observed beneficial effect of NAC should disappear when -glutamylcysteine ligase, which catalyzes the first step in the GSH biosynthesis pathway, is inhibited by buthionine sulfoximine (BSO) [17]

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Intestine-specific metabolic processes are also essential for hormone regulation, particularly incretin hormones, which enhance glucose homeostasis