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Excessive pyroptosis leads to rapid rupture of the plasma membrane and the excessive release of proinflammatory cytokines and chemokines, which results in neuroinflammation that triggers a cascade of secondary injuries culminating in neuronal death

Notably, this treatment markedly decreased glutathione levels in splenocytes of male and female mice (Fig

Moreover, evidence suggests connection between the SN, periaqueductal gray, and the RTN (Lima et al., 2018

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