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Its dosage and results depend upon body weight as well as the color of skin for eg

doi: 10.3947/ic.2013.45.1.32 [DOI] [PMC free article] [PubMed] [Google Scholar] 255

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Catecholamines increase T 4 to T 3 conversion, by stimulating activity of a specific deubiquitinase that acts on the D2 protein, upregulates D2 activity, and increases T 3 levels in the nucleus (90)

143 A large body of evidence demonstrates that oxLDL is closely associated with coronary and peripheral artery disease, hypertension, ischemic stroke and acute coronary syndrome, as well as cardiovascular risk factors including diabetes, obesity, chronic inflammation, and metabolic syndrome