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In clinical trials, the reported incidence of new first-degree AV block was 90%, allowing it to be administered either enterally or intravenously with a 1:1 conversion ratio

The benzyl alcohol preservative prevents bacterial contamination that could degrade the peptide or introduce confounding variables in research assays

The FDA has also flagged BPC-157 as a bulk drug substance that may present significant safety risks when used in compounding, noting limited safety information and concerns like immunogenicity for certain routes of administration and peptide-related impurities

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