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In gastrointestinal stromal tumors, cotreatment of imatinib and autophagy inhibitors (like chloroquine) cause apoptosis [356, 357].The endoplasmic reticulum (ER) is an essential subcellular structure that maintains cellular homeostasis and can be disrupted by a variety of pathological conditions like cancer, resulting in induction of ER stress which if remains sustained can either kill cancer cells by induction of apoptosis and ferroptosis or help them to grow, survive and induce drug resistance if moderately activated [358]

Acta 1827 , 401410 (2013)

doi: 10.1002/mus.20385 56

In summary, Hcy induces redox imbalance, increases oxidative stress, and triggers the production of free radicals in various cell types, including endothelial, glial, and neuronal cells, thereby contributing to several neurological disorders [70]

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