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These mechanisms include efficient recycling through the vitamin B12-dependent methionine synthase, which is the sole enzyme in the brain responsible for converting Hcy into methionine

Jama Pediatr

Serotonergic System Shows Regional Specificity With Antidepressant Potential The April 2024 paper highlights substantia nigra serotonin increases as one of BPC-157s most consistent and robust effects, supported by gold-standard autoradiography measuring actual synthesis rates rather than just concentration