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ROS also played an important role in the release of cytochrome c and other pro-apoptotic proteins, which can trigger caspase activation and apoptosis

Cortisol stress reactivity across psychiatric disorders: A systematic review and meta-analysis

doi: 10.1016/s0014-5793(97)00380-3

Prolonged heroin use leads to receptor downregulation and desensitization mediated by G protein-coupled receptor kinase and arrestin (Pasternak, 2012)