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As previously mentioned, examples of longevity resulting from disruption of the GH/IGF-1 and/or insulin signaling pathway are mainly derived from early life manipulations 6,17,18 , whereas brief exposure to GH (and IGF-1) treatment early in development is sufficient to partially abrogate the exceptional longevity of Ames Dwarf mice 20

[DOI] [PubMed] [Google Scholar] 41.El-Mowafy AM, Al-Gayyar MM, Salem HA, El-Mesery ME, Darweish MM

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Med., 197(1), 2731.