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In addition to genetic approaches, a pharmacological tool that has frequently been used to deplete glutathione is buthion- ine sulphoximine (BSO), a specic inhibitor of g-ECS (Grif- th & Meister 1979)

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Marks points out that at that time the two hormones produced by pancreatic islet A and B cells were regarded as 'biological antagonists rather than subtle collaborators in blood glucose control' (Marks 2018)

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lowest tolerated dose Phase Step 2 Weeks Weeks 5-8 Cagrilintide Dose 0.5 mg/week Purpose Dose escalation Phase Step 3 Weeks Weeks 9-12 Cagrilintide Dose 1.0 mg/week Purpose GI side effects often peak here Phase Step 4 Weeks Weeks 13-16 Cagrilintide Dose 1.7 mg/week Purpose Approaching maintenance Phase Maintenance Weeks Weeks 17+ Cagrilintide Dose 2.4 mg/week Purpose Target dose used in late-stage study protocols Each step lasts 4 weeks