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Rapid escalation increases side effect severity, particularly nausea and gastrointestinal distress

They are also expressed in vascular and lymphatic endothelia, affecting proliferation, migration, angiogenesis, as well as the formation of small lymphatic vessels and capillaries 313

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this is characterized by a decrease in mitochondrial volume and membrane density, a reduction or disappearance of cristae structures, rupture of the outer membrane, and other morphological changes [21]

Furthermore, they discovered interesting shifts in the relative abundance of intestinal microbiota compared to a control group