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Although the above mechanisms have been discovered and confirmed repeatedly, therapeutic strategies should be more specifically targeted to mitochondrial energy defects rather than the neuroprotective effects of antioxidants [52]

Clinically approved iron chelators such as deferoxamine (DFO) and deferiprone (DFP), which are used to treat systemic iron overload, have demonstrated potential antifibrotic effects through inhibition of ferroptosis

Cell Mol Life Sci 69:33813394 Dringen R, Hamprecht B, Broer S (1998) The peptide transporter PepT2 mediates the uptake of the glutathione precursor CysGly in astroglia-rich primary cultures