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Moreover, ROS can directly target ETC complexes, especially complex I and complex III, causing electron leakage and amplifying ROS production, which further intensifies oxidative stress and mitochondrial dysfunction [26]

But actually there's more common causes of muscle spasms and often it has to do with electrolytes

(2001) Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration, J

This reactive metabolite produces conjugation adducts for many cellular proteins, including those involved in the mitochondrial ETC and others [110, 268, 269]

Biochemical evidence reliability is of significant importance due to the limitations in the effectiveness of non-invasive localization methods like CT and MRI, as well as the need for specialized imaging modalities and expert staff [70]