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10.1016/j.rbmo.2024.103815 400 YaoJ.ZhengJ.CaiJ.ZengK.ZhouC.ZhangJ.et al (2019a)

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Additionally, curcumin modulates Sirt1-Foxo1 signaling and enhances PI3K-Akt activity, leading to restored Akt phosphorylation, decreased pro-apoptotic signaling, and improved cellular antioxidant defenses