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reported that unexplained liver injury in PCOS patients and animal models was accompanied by increased Fe deposition and downregulation of hepcidin and GPX4 expression in the liver, indicating the importance of iron metabolism in this type of unexplained liver injury (165)

Excessive toxin concentrations in the liver can deplete glutathione levels, leading to severe liver damage

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Infection with certain pathogens can also increase the risk of cancer in this group (see Sidebar 15 )

De Moura e Dias, M., Aparecida dos Reis, S., Lopes da Conceio, L., Nogueira de Oliveira Sediyama, C