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While in vitro BM systems are undoubtedly valuable, we limit our discussion to in vivo models, with a focus on progress in patient-derived xenograft and organoid models

Combination of Western diet with CCl 4 administration resulted in rapid development of liver steatosis, inflammation, hepatocellular ballooning, and severe fibrosis, moreover, transcriptomic analysis showed that dysregulated molecular pathways were comparable to those of human MASH (Tsuchida et al

Their depletion and functional impairment, driven by a hostile degenerative microenvironment and dysregulated signaling pathways, are critical factors in disease progression

Leukemia 22 , 11911199 (2008)

The endothelial lining on the vessel wall is crucial for nutrients and oxygen supply to the tissue