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These metabolites are excreted primarily through urine and bile, with bioavailability depending on the administration route

Even brief exposure to small amounts can cause severe lung damage

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Third, CpG recognizes TLR9 on human B cells and plasmacytoid dendritic cells (pDCs), while TLR9 activation in T cells and monocytes/macrophages further drives cytokine and chemokine secretion (Xie et al., 2024