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Most significantly, the association of misfolded and dysfunctional SOD1 protein with dopaminergic neuron loss in Parkinson's disease suggests that many of the therapies currently being trialled for their ability to influence misfolded mutant SOD1 biochemistry in SOD1 linked familial ALS (Table 3) may also constitute novel diseasemodifying treatments for Parkinson's disease

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When Depakote ER is used in this patient group, it should be used with extreme caution and as a sole agent

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