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Description

Low intracellular levels of GSH cause impaired secretion of IL-12 in macrophages, leading to diminished production of IFN- in NK cells (222)

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As GPX4 activity is heavily dependent on GSH availability, upregulation of SLC7A11 enhances GPX4 function and prevents ferroptosis

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doi: 10.1007/s00203-022-03037-y 152 KovE.TkovZ.BhideK.KulkarniA.Jimnez-MunguaI.MertinkovP.et al

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