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This ACC acetylates histone H3K27, promoting NFYA expression, which ultimately upregulates DLD, PKM2, and IDH1, enhancing glycolysis and proliferation of PASMCs

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Additionally, miRNA alterations have been found as well, as it were shown decreased miR-127 and miR-146-b levels in rat mammary tissues following both acute and prolonged light-dark alterations 221

2 : 589598 Haimovitz-Friedman A, Khan CC, Ehleiter D, Persaud RS McLoughlin M, Fuks Z and Kolesnick RN (1994) Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis