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There is also concern about the potential for excessive or rapid weight loss when combining treatments, which may increase the risk of nutritional deficiencies, particularly in protein, vitamins, and minerals

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5-Amino-1MQ inhibits NNMT (nicotinamide N-methyltransferase), an enzyme that depletes NAD+ and promotes fat storageraising NAD+ increases mitochondrial respiration and thermogenesis

Supplementing with vitamin B12 is particularly common, because deficiency is widespread